Drug Delivery System

  • R&D
  • Drug Delivery System

Drug Delivery System


  • LNP (Lipid Nano Particle), the most well-known form, is also referred to as artificial cells or liposomes depending on the field, and it is commonly used as a drug delivery system.
  • LUCA AICell is conducting research to create LNP with more precise and uniform sizes.

Manufacturing uniform LNPs of various sizes

In addition to conventional methods that utilize structural and fluid dynamics principles
such as microfluidics and extrusion, LUCA AICell has its unique approach based on
thermodynamic principles to manufacture LNPs.
This allows for more sophisticated control tailored to specific projects.

Diverse LNP Libraries based on the seven engineering variables

[Simulation based on a database accumulated from research conducted since in 2007]

  • By taking into account diverse factors such as size, charge, and pH, as well as
    manipulating engineering variables based on lipid properties, we can effectively
    transport desired medications to specific cells with stability.
  • All LNP research conducted at LUCA AICell is documented and managed in a database.

Tae H, Park S, Ma GJ, Cho NJ

Nanoarchitectured air-stable supported lipid bilayer incorporating sucrose–bicelle complex system.

Nano Convergence, 2022, 9: 3.


Park H, Sut TN, Yoon BK, Zhdanov VP, Kim JW, Cho NJ*, Jackman JA

Multivalency-Induced Shape Deformation of Nanoscale Lipid Vesicles: Size-Dependent Membrane Bending Effects.

The Journal of Physical Chemistry Letters, 2022, 13: 1480-1488.


Ferhan AR, Park S, Park H, Tae H, Jackman JA*, Cho NJ

Lipid Nanoparticle Technologies for Nucleic Acid Delivery: A Nanoarchitectonics Perspective.

Advanced Functional Materials, 2022: 2203669.


Sut TN, Ferhan AR, Park S, Koo DJ, Yoon BK, Jackman JA, and Cho NJ

Modulating noncovalent and covalent forces to control inverse phosphocholine lipid self-assembly on inorganic surfaces:

Applied Materials Today, 2022, 29: 101618.


Hyeonjin Park, Tun Naw Sut, Bo Kyeong Yoon, Vladimir P. Zhdanov, Nam-Joon Cho, and Joshua A. Jackman

Unraveling How Cholesterol Affects Multivalency-Induced Membrane Deformation of Sub-100 nm Lipid Vesicles

Langmuir, 2022